How To Choose The Best Berberine Supplement?

Berberine is a powerful supplement with benefits for blood sugar and insulin resistance(4), cholesterol(2), metabolism, and weight control(1)—but not all supplements are created equal. The best berberine supplement depends on absorption, effectiveness, and personal needs. Always read the back label to ensure no fillers or unnecessary ingredients like fillers, sweeteners, bulking agents, etc. 

Here’s a breakdown of the most popular formulations of Berberine Supplements:

1. Berberine HCl (Hydrochloride) – Most Natural Version

This is the most common and well-researched form of berberine supplement. While its absorption is not as good as newer versions, it’s still highly effective and is the most affordable. It is extracted from plants like goldthread, barberry, and tree turmeric and minimally processed -purified, and converted into hydrochloride (HCl) for better stability and absorption.

Best for: General metabolic health support in a natural way. 

2. Berberine with Bioenhancers (Piperine, Milk Thistle, Cinnamon, etc.)

Some supplements combine berberine with ingredients that enhance absorption and effectiveness. For example, piperine (from black pepper) slightly boosts bioavailability, while milk thistle supports liver health and metabolism.
Best for: Those looking for added benefits and enhanced effects.

3. Dihydroberberine (DHB) – Most Bioavailable

Dihydroberberine is a more absorbable version of berberine, which can be absorbed over 6 times better than HCl.(5) Once inside the body, it converts into active berberine. It’s also gentler on the digestive system, making it a good option for people who experience upset stomachs with regular berberine supplements. Technically, it’s still berberine but undergoes an extra step—it’s a metabolized version of berberine that forms naturally in the gut. It is created through a synthetic conversion process to mimic how the body breaks down berberine HCl.

Best for: Those with digestive sensitivity or who want maximum effectiveness.

2. Berberine with Cyclodextrin (Berberine Phytosome) – Best for Absorption But Most Processed

This newer formulation improves absorption by pairing berberine with cyclodextrin(3), which helps the body absorb it up to 10 times better than standard Berberine. This means you can get stronger effects with a lower dose. However, it is highly processed to enhance bioavailability, so it is more like a pharmaceutical formulation than a direct plant extract.

Best for: Those who struggle with absorption or want a more potent berberine supplement.

Which Berberine is the best for you? 

• For general health & blood sugar balance: Berberine HCl (most studied, budget-friendly, and natural version).
• For better absorption with a lower dose, Dihydroberberine or Berberine Phytosome.
• If you have digestive issues, take  Dihydroberberine
• For added benefits: A blend with bio-enhancers like piperine or milk thistle.