Berberine exploded in popularity over the last few years. I have also added it to my daily supplement routine to regulate cholesterol and blood glucose and help with food cravings. However, regular berberine can have poor absorption, hence why I want to explore Dihydroberberine (DHB), which is a hydrogenated derivative of berberine (BBR) that shows significantly improved bioavailability compared to berberine. In this article, I want to list the best Dihydroberberine supplements that have strong and clean formulations that work and don’t have any unnecessary fillers.
TL;DR
Dihydroberberine (DHB) is a more bioavailable and potentially more effective version of berberine. It offers improved stability, better absorption, and promising metabolic benefits, while being gentler on the gut.
- Best Dihydroberberine: Refined Root Dihydroberberine 300 mg + Alpha Lipoic Acid 600 mg (60 servings, 3rd-party tested, strong dose, synergistic add-on)
Why Choose DihydroBerberine Supplement?
What Is Dihydroberberine (DHB) and Why Is It Different from Berberine?
Dihydroberberine (DHB) is a newer, improved form of berberine – a plant compound often used to support blood sugar, heart health, and metabolism.
Your body does not absorb regular berberine very well. Only a small amount actually makes it into your bloodstream, and it is quickly broken down.
DHB was developed to solve this issue.
Better absorption and higher effectiveness
Compared to standard berberine, DHB:
Is absorbed more efficiently in the intestines
Leads to higher levels in the bloodstream
Stays active in the body longer (3)
Because of this improved absorption, DHB may have stronger effects at lower doses.
It works partly by activating AMPK, sometimes called the “metabolic master switch.” AMPK helps regulate blood sugar, fat metabolism, and energy production. DHB also appears to have antioxidant effects, which support overall cellular health.
Dihydroberberine is a more absorbable version of berberine, which can be absorbed over 6 times better than HCl.(1) Once inside the body, it converts into active berberine.
It’s also gentler on the digestive system, making it a good option for people who experience upset stomachs with regular berberine supplements.
Technically, it’s still berberine, but it undergoes an extra step; it’s a metabolized version of berberine that forms naturally in the gut. It is created through a synthetic conversion process to mimic how the body breaks down berberine HCl.
Various studies and clinical trials have proven that DHB is more effective in the management of metabolic syndrome, type 2 diabetes, and cardiovascular disorders as compared to traditional berberine. (2)
Dihydroberberine supplement is best for: Those with digestive sensitivity or who want maximum effectiveness.
If you are looking for regular berberine, with clean formulas, check out: The Best Berberine Supplements of 2026.
Disclaimer: This post contains affiliate links, and I may earn a small commission if you buy through them at no extra cost. For more details, please check out my Affiliate Disclosure. Thank you for supporting BarefootBasil.
The Best Dihydroberberine supplements
1. Refined Root
Dihydroberberine 300mg with Alpha Lipoic Acid 600mg Supplement
Strength Per Serving: 300 mg
Amount of Servings: 60 (2 capsules)
Ingredients: Dihydroberberine, Alpha Lipoic Acid, Vegetable Cellulose Capsule
3rd Party Tested: Yes
Vegan: Yes
Dihydroberberine and Alpha Lipoic Acid [ acido alfa lipoico 600mg ] work synergistically to support metabolic health and overall metabolic efficiency.
2. Nutri
Dihydroberberine Supplement With Ceylon Cinnamon
Strength Per Serving: 100 mg
Amount of Servings: 60 (1 capsule)
Ingredients: Dihydroberberine, Organic Ceylon Cinnamon Extract, Vegetable Cellulose Capsule
3rd Party Tested: Yes
Vegan: Yes
It is a great, affordable option for people who struggle with digestive issues. Quite a small dose.
3. NutraBio
Berberine Advanced (Dihydroberberine)
Supplement
Strength Per Serving: 200 mg
Amount of Servings: 60 (1 capsule)
Ingredients: Dihydroberberine, Vegetable Hypromellose Capsule
3rd Party Tested: Yes
Vegan: Yes
A clean and 3rd party tested Dihydroberberine, but it is a bit pricey.
5. Neurogan Dihydroberberine Supplement Capsules
Strength Per Serving: 250 mg
Amount of Servings: 60 (1 capsule a day)
Ingredients: Dihydroberberine, vegetable cellulose
3rd Party Tested: Yes
Vegan: Yes
5. Peak Performance GlucoVantage Super Berberine
Strength Per Serving: 250 mg
Amount of Servings: 30 (1 capsule a day)
Ingredients: Dihydroberberine (DHB) as GlucoVantage®, vegetable stearate, cellulose, and cellulose capsule.
3rd Party Tested: Yes
Vegan: Yes
The Best Dihydroberberine supplements with extra ingredients
1. Altavida
Balance Dihydroberberine Super Berberine Supplement with Ceylon Cinnamon
Strength Per Serving: 250MG
Amount of Servings: 30
Ingredients: Dihydroberberine (DHB), Ceylon Cinnamon Extract, Milk Thistle Extract, Vegetable Cellulose (capsule), Rice Bran Extract, Rice Hulls, Gum Arabic, Sunflower Oil
3rd Party Tested: Yes
2. NUSORAN
Dihydromyricetin
Supplement
Strength Per Serving: 300 mg
Amount of Servings: 50 (1 capsule a day)
Ingredients: GlucoVantage Dihydroberberine, Resveratrol, Ceylon Cinnamon, Metabolic Vitality Blend (Gymnema Sylvestre, Ashwagandha, Bitter Melon), Cardiovascular Support Blend (Coenzyme Q10, Grape Seed, Green Tea, Curcumin)
3rd Party Tested: Yes
3. Camvora
Dihydroberberine – GlucoVantage
Strength Per Serving: 250 mg
Amount of Servings: 150 (1 capsule a day)
Ingredients: GlucoVantage Dihydroberberine, Ceylon Cinnamon, All in 1 metabolic, heart & Digestive support blend (ashwagandha, Bitter Melon, Fenugreek, Tumeric), Black Pepper.
3rd Party Tested: Yes
Recommended Dihydroberberine Supplement Dosage
- Dihydroberberine: 100–150 mg twice a day, but also read your supplement label and consult with your healthcare providers for a more precise dosage.
Please Note:
Berberine has many science-proven benefits, but should be avoided by pregnant and breastfeeding women, children, and those with liver or kidney disease due to potential toxicity. It can also interact with medications, including blood sugar and blood pressure drugs, blood thinners, and those metabolized by liver enzymes (like certain antidepressants and statins), increasing the risk of side effects. People with digestive sensitivities may experience gastrointestinal discomfort, and those on multiple medications should consult a healthcare provider before use.
If you’re considering berberine, consult a doctor or nutritionist—especially if you’re on medication or have an existing health condition.
You might also like:
How did we select the best Dihydroberberine Supplements?
We begin by analyzing the ingredient lists on product labels, ensuring that there are no unnecessary additives, such as bulking agents or artificial flavors.
Next, we review the brand or seller to confirm their legitimacy and reputation within the wellness community. We prioritize products that are third-party tested and hold accredited certifications.
We use fake review detection technology to analyze customer feedback on marketplaces like Amazon and Walmart.
We highlight high-potency formulas made with clean, ethical ingredients. Sustainable, vegan, and cruelty-free products are at the top of our list.
While we can’t test every product ourselves, we do so whenever possible to ensure our recommendations reflect real-world quality and effectiveness.
References
- Moon JM, Ratliff KM, Hagele AM, Stecker RA, Mumford PW, Kerksick CM. Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial. Nutrients. 2021 Dec 28;14(1):124. doi: 10.3390/nu14010124. PMID: 35010998; PMCID: PMC8746601. https://pubmed.ncbi.nlm.nih.gov/35010998/
- Agarwal, A. (2025). Beyond Berberine: The Therapeutic Revolution of Dihydroberberine. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT. https://doi.org/10.55041/ijsrem51151.
- Chang, C., Roh, Y., Du, M., Kuo, Y., Zhang, Y., Hardy, M., Gahler, R., & Solnier, J. (2024). Differences in Metabolite Profiles of Dihydroberberine and Micellar Berberine in Caco-2 Cells and Humans—A Pilot Study. International Journal of Molecular Sciences, 25. https://doi.org/10.3390/ijms25115625.
Silvija Meilunaite, PN1-NC, CSMC, is a certified nutrition and menopause coaching specialist who writes about midlife health, nutrition, and evidence-based wellness. She focuses on research-driven approaches to feeling better in your 40s and beyond, with a special interest in low-tox living and supportive daily habits.
